The REACH Project

Russian European Alliance for research among women, Children and adolescents impacted by HIV, TB and HCV

REACH is a collaborative effort to fill the knowledge and data gaps on the HIV epidemic affecting children, adolescents and pregnant women across Russia. It will provide new data on long-term antiretroviral therapy toxicity, HIV resistance, Hepatitis C virus and Tuberculosis coinfections and comorbidities in this setting.

The REACH Project

Russian European Alliance for research among women, Children and adolescents impacted by HIV, TB and HCV

REACH is a collaborative effort to fill the knowledge and data gaps on the HIV epidemic affecting children, adolescents and pregnant women across Russia. It will provide new data on long-term antiretroviral therapy toxicity, HIV resistance, Hepatitis C virus and Tuberculosis coinfections and comorbidities in this setting.

Background

Pregnant women, children and adolescents are priority populations in the global public health response to the epidemics of human immunodeficiency virus (HIV), tuberculosis (TB) and hepatitis C virus (HCV). The intersecting epidemics for these three infections are particularly marked in Eastern Europe and present major public health and societal challenges.

The REACH alliance will explore the use of new diagnostics and preventive TB treatment, as well as the use of novel direct acting antivirals for HCV in children in real-world setting. In addition, REACH will promote geographic expansion of the collaborative research in maternal and child health in Europe with a broad and long-lasting impact. Moreover, it will invest in and enable future research partnerships through Russian and European harmonization of research instruments and methodologies, knowledge sharing, multi-media training and delivery of collaborative protocols for future studies.

REACH wants to ensure the voices of patients are central to this project at all levels. Therefore, the two Youth Advisory Boards (YABs) are an integral part of REACH. They involve young people aged between 15-19 and include those affected by HIV, TB and/or HCV. The YAB members will be engaged across REACH, with a focus on creating patient and public friendly information on the project and its findings.

The REACH Network

The REACH project builds on long-standing, successful collaboration between experts in paediatric and maternal HIV, TB and HCV from the Russian Federation and other European countries. The REACH consortium brings together established clinical research networks with track records of delivering innovative research on HIV, TB and HCV in children, adolescents and pregnant women. These include the long-standing Penta network, incorporating the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) and PENTAHep, alongside the Pediatric Tuberculosis Network European Trials group (pTBnet).